Molecular Basis Distinguishing the DNA Binding Profile of Nrf2-Maf Heterodimer from That of Maf Homodimer
نویسندگان
چکیده
منابع مشابه
Predictive base substitution rules that determine the binding and transcriptional specificity of Maf recognition elements.
Small Maf transcription factors possess a basic region-leucine zipper motif through which they form homodimers or heterodimers with CNC and Bach proteins. Different combinations of small Maf and CNC/Bach protein dimers bind to cis-acting DNA elements, collectively referred to as Maf-recognition elements (MAREs), to either activate or repress transcription. As MAREs defined by function are often...
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The erythroblastic island was ultrastructurally identified as a common organizational unit of bone marrow more than 50 years ago.2 Erythroblastic islands are composed of erythroblasts, at various stages of maturation, and a central macrophage. The central macrophage supports erythroid cell survival and proliferation through intercellular signaling, and facilitates enucleation.3 Along this line,...
متن کاملDifferential expression of maf-1 and maf-2 genes in the developing rat lens.
PURPOSE To examine the expression of maf-1 and maf-2 protocogenes in the developing rat lens. METHODS Maf-1 and maf-2 transcripts were assayed in rat lenses on embryonic days 13 and 16 (E13 and E16) by in situ hybridization using single-stranded RNA probes. Proteins encoded by the maf-2 gene were assayed immunocytochemically in embryonic (E12, 13, 16, 19) and postnatal day 14 and 90 (P14 and ...
متن کاملThe world according to Maf.
Maf family proteins are so named because of their structural similarity to the founding member, the oncoprotein v-Maf. The small Maf proteins (MafF, MafG and MafK), as do all family members, include a characteristic basic region linked to a leucine zipper (b-Zip) domain which mediate DNA binding and subunit dimerization respectively. The small Maf proteins form homodimers or heterodimers with o...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m706863200